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Laboratory Director- Somatic

Company: Ambry Genetics
Location: Aliso Viejo
Posted on: March 26, 2020

Job Description:

Ambry Genetics is seeking a full-time Laboratory Director to establish clinical reporting operations for our developing precision medicine efforts. This individual will lead the development of a team to establish curation, analysis, interpretation, and reporting workflows for tumor profiling in solid tissue and blood. This is an excellent opportunity for an independent, creative, service-oriented person to be involved at the leading edge of genetic testing.

Ambry Genetics is a company of many firsts, including the first clinical exome test and the first multi-gene hereditary cancer panel. The clinical team provides scientific, quality-driven, and accurate results across a variety of specialties to providers and patients. This is a collaborative effort between board-certified laboratory directors and genetic counselors, variant assessment and clinical genomics scientists, and computational biologists. In addition to routine operations, the clinical team is involved in clinical research in different areas, including variant classification resolution, and supports pharmaceutical partner trials.

Job duties for the Laboratory Director include:


  • Lead the development of a somatic reporting operations team, including selection, design, and implementation of scalable workflows for curation, variant analysis and interpretation, and reporting.
  • Develop training program for technical and non-technical staff.
  • Review of test validation data and standard operating procedures.
  • The review and sign out of clinical test reports for healthcare providers and pharmaceutical partner studies. This includes interpretation of diagnostic test results and review of variant classification.
  • Providing technical and clinical support regarding test results for internal staff and ordering clinicians.
  • Participation in quality assurance/quality control and quality improvement of testing processes.
  • Other duties and regulatory responsibilities as delegated by the CLIA Laboratory Director to support clinical and pharma services.

    Position requirements include:

    • Hold an M.D. or Ph.D. degree in a field related to molecular biology/genetics
    • Current ABMGG certification or active candidate in Molecular Genetics or Cytogenetics, or ABP board certification or eligibility in Molecular Pathology
    • PhD candidates should also hold or be eligible for a:


      • Assistant: California Clinical Genetic Molecular Biologist Scientist (CGMBS) license
      • Associate: California Clinical Laboratory Director (CGMB) license.
      • MD candidates should also hold or be eligible for a:


        • California Medical License
        • NYSDOH, Certificate of Qualification (COQ) or eligibility in Molecular Oncology
        • Extensive experience in somatic reporting operations.
        • Thorough and ongoing knowledge of somatic variant classification and functional interpretation of somatic variants, preferably according to established professional guidelines (e.g., AMP or ESMO).
        • Familiarity with professional guidelines for the diagnosis or treatment of cancer, as published by NCCN, ESMO, ASCO or the WHO.
        • Knowledge of molecular laboratory technology and operations, regulatory requirements, and professional guidelines.
        • Experience with cell free DNA, solid tissue, and/or next-generation sequencing based assays.
        • Excellent written and verbal communication skills to convey difficult information in a clear, kind, and respectful manner.
        • Willingness and ability to work in and contribute to a fast-paced, highly collaborative environment.

          About Us

          Ambry Genetics Corporation is a CAP-accredited and CLIA-licensed molecular genetics laboratory based in Aliso Viejo, California. We are a genetics-based healthcare company that is dedicated to open scientific exchange so we can work together to understand and treat all human disease faster.

          At Ambry, everyone is welcome. A career at Ambry Genetics is a chance to be part of a dynamic company that aims to improve health by understanding the relationships between genetics and human disease. We earned our reputation as industry leaders by responsibly introducing cutting-edge genetic testing solutions and continually sharing what we learn with the global scientific community.

          At Ambry you will be learning, challenging yourself, and having fun while collaborating with teammates through the open exchange of ideas. Employees at Ambry Genetics have many perks, including an onsite caf-- with complimentary smoothies and infused waters! We also offer access to gym memberships, onsite food trucks,"Lunch and Learns," and more. Our outstanding benefits program includes medical, dental, vision, 401k, FSA, and generous paid time off (PTO) program. Ambry Genetics is an Equal Opportunity Employer (EOE) and we maintain a drug-free work environment.

          Ambry Genetics is an Equal Opportunity Employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, or protected veteran status and will not be discriminated against on the basis of disability.

Keywords: Ambry Genetics, Aliso Viejo , Laboratory Director- Somatic, Healthcare , Aliso Viejo, California

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